Core Facilities
The ÐÇ¿Õ´«Ã½ has state-of-the-art research infrastructures that are available to researchers and external users as service and technology centers within the framework of Core Facilities. Some cost-intensive infrastructures are assigned to a professorship as a shared facility and can be used within the framework of collaborations. As a comprehensive university, the ÐÇ¿Õ´«Ã½ offers the opportunity to promote interdisciplinary collaboration and to research scientific topics with teams from different disciplines.
Core Facilities of the ÐÇ¿Õ´«Ã½
Microscopy Network Basel
The (MNB) is an association of academic microscopy facilities in the Basel region and is supported by the Departments of Biozentrum and Biomedicine of the ÐÇ¿Õ´«Ã½, the Department of Biosystems Science and Engineering (D-BSSE) of ETH Zurich and the Friedrich Miescher Institute (FMI). The MNB aims to foster collaborations and scientific exchange in the field of bioimaging by organizing courses, workshops and seminars to mutually utilize existing resources and infrastructures in the field of light microscopy.
BioEM Lab
The at the Biozentrum offers high-resolution imaging techniques of macromolecules, cells and tissues using transmission electron microscopy (TEM and CryoTEM) and as 3D reconstruction of proteins and cells using single particle approach and electron tomography.
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Imaging Core Facility
The of the Biozentrum is a technology platform for the use of highly sophisticated light microscopes. It provides image analysis support to research groups and makes state-of-the-art microscopy techniques and software solutions available to scientists.
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Microscopy Core Facility
The of the Department of Biomedicine at the ÐÇ¿Õ´«Ã½ provides equipment and expertise in the field of high-end microscopy and image analysis at two locations. The Facility supports researchers on a daily basis in the acquisition of everything from simple histology images to super-resolution microscopy in living cells or customized programs for automation and analysis.
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Flow Cytometry Core Facility
The of the Department of Biomedicine at the ÐÇ¿Õ´«Ã½ is a state-of-the-art scientific platform that provides researchers with instruments and expertise and enables the use of current flow cytometry techniques in translational and basic research projects.
More than 300 researchers use ten flow cytometry analyzers (6 BC CytoFLEX and 4 BD Fortessas), five cell sorters (4 BD FACSAria™III and one BD FACSMelody™), three high-end spectral analyzers (Cytek® Aurora) and one imaging cytometer (AMNIS® ImageStream X Mk II).
Our team provides training on instrument operation, cell sorting procedures, experimental design consulting, data analysis support, and expert seminars.
Director: Dr. Morgane Hilpert
Contact: flowteam-dbm@unibas.ch
Good Manufacturing Practice (GMP) Core Facility
The (GMP-FAT) of the Department of Biomedicine is an association of two GMP laboratories at the Zentrum für Lehre und Forschung and Klinikum 2 of the University Hospital Basel. The GMP-FAT Core Facility provides research groups with expertise, infrastructure and the Pharmaceutical Quality System (PQS) for the manufacture of Advanced Therapy Medicinal Products (ATMPs: products for somatic cell therapy, tissue therapy and gene therapy) used in phase I and II clinical trials.
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Bioinformatics
The is the competence center of the Department of Biomedicine in the field of computational biology and biostatistics. It offers tailor-made solutions for analysis, visualization and interpretation of complex biological data, especially in the field of high-throughput genomics and proteomics. Consulting and teaching complete the offer.
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Histology Core Facility
The of the Department of Biomedicine provides services and support to researchers in the field of standard and high-end histology and histopathology, from sample preparation to automated image analysis.
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Contact: histology-dbm@unibas.ch
Genomics Facility Basel
The is operated by the ÐÇ¿Õ´«Ã½ and the (D-BSSE) of ETH Zurich and offers services in the field of genome sequencing and analysis with state-of-the-art sequencing systems. Projects of all kinds – from tumor characterization at single cell resolution to the assembly of complete genomes of microorganisms, animals and plants – are supported.
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Proteomics Core Facility
The at the Biozentrum provides expertise and resources to researchers in the field of biological mass spectrometry and is involved in the development of new quantitative and qualitative methods for the analysis of proteins and their modifications.
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Nuclear Magnetic Resonance – Swiss High-field NMR Facility
The Biozentrum uses (NMR) to investigate the structure, dynamics and interactions of biomolecules in order to understand and modify their function, for example with regard to diseases or drugs. In addition, NMR spectroscopy is being further developed for the study of proteins.
Together with the University of Zurich and ETH Zurich, the was established to provide researchers with access to the most powerful equipment in the field of high-field NMR spectroscopy. Researchers of the ÐÇ¿Õ´«Ã½ can use the facility within a fixed quota of measurement time.
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Contact: Alexandra Meng
Magnetic Resonance Imaging (MRI)
At the , a 3 Tesla whole-body magnetic resonance tomograph (Siemens Magnetom Prisma) with a powerful gradient system (80 mT/m @ 200 T/m/s) and high field homogeneity (0.2 ppm at 40 cm DSV) is available for human studies. The system also has a second broadband amplifier for excitation of non-proton nuclei. The scanner is mainly used for research projects in Radiological Physics, but can also be shared by other research groups.
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Nano Imaging Lab
The of the (SNI) is a service platform for imaging and analysis of nanostructures. It has various scanning electron microscopes (SEM and cryo-REM), transmission electron microscopes (TEM) and atomic force microscopes (AFM). It also offers focused ion beam (FIB) technology, confocal microscopy and various spectroscopic analysis capabilities.
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Center for Medical Image Analysis & Navigation
The (CIAN) develops new tools and methods in the field of medical imaging. This involves, for example, optimizing processes in computed tomography and magnetic resonance imaging, developing learning algorithms for faster and more precise evaluation of medical images, or making this data available in virtual and augmented reality for surgery planning, patient education and training.
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Micro- and Nanotomography
The Core Facility (MiNa) of the DBE at the ÐÇ¿Õ´«Ã½ offers the possibility to visualize objects non-destructively with micro- or even submicrometer resolution using hard X-rays. The nanotom® m system from phoenix|x-ray, GE Sensing & Inspection Technologies GmbH, Wunstorf, Germany, and the Skyscan 1275, Bruker microCT, Kontich, Belgium, are available. The three-dimensional data are so large that quantitative analysis is usually performed automatically. The Core Facility is also available to external users from science and industry.
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3D Print Lab
The and the (Medical Additive Manufacturing) research group at the DBE work closely together on 3D surgical planning and medical 3D printing including bioprinting (3D printing of cells and support structures), high-performance materials, smart implants, image analytics and segmentation techniques. Patient-specific models are printed from MRI or CT data for use in the clinics of the University Hospital Basel.
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Center for Transgenic Models
The (CTM) service platform provides researchers with comprehensive services and expertise in the field of transgenic animal models, in particular the generation and cryopreservation of mouse strains. CTM offers a variety of standard techniques and develops new gene delivery methods, professionally implementing the 3Rs principles for responsible animal experimentation.
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Contact: ctm@unibas.ch
sciCORE
is the competence center for scientific computing and provides the infrastructure for high-performance computing, storage and processing of scientific data. sciCORE implements innovative computing solutions in close collaboration with researchers and offers training and consulting to scientists. sciCORE is also a Core Facility of the and one of the BioMedIT nodes supporting the project.
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Contact: scicore@unibas.ch
Center for Data Analytics (CeDA)
The (CeDA) is an interdisciplinary competence center for quantitative data analysis at the ÐÇ¿Õ´«Ã½. The consulting and support services of the CeDA are provided by data analysts with expertise in biomedicine, natural sciences, and social sciences and humanities. The activities of the CeDA are coordinated by , the (DHLab) and the Data Analytics Professorship at the Department of Mathematics and Computer Science.
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Contact: Dr. Geoffrey Fucile
Swiss National Data and Service Center for the Humanities (DaSCH)
The is a national research infrastructure that guarantees long-term access to research data in the humanities according to FAIR principles. DaSCH is hosted by the ÐÇ¿Õ´«Ã½ as an association on behalf of the SNSF. It is available to all researchers in Switzerland to keep qualitative humanities research data available online in the long term, even after the end of projects.
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Contact: info@dasch.swiss
Research and Infrastructure Support (RISE)
The Core Facility (RISE) supports researchers in the humanities and social sciences at the ÐÇ¿Õ´«Ã½ in issues related to the design of computer-based research, the production and analysis of data, digital editions and user-oriented visualization of data, and the sustainable and open availability of data. RISE is based at the and the of the ÐÇ¿Õ´«Ã½.
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Contact: rise@unibas.ch
